IBS Life Science Institute

3AIM-seq: Quality assessment of mRNA therapeutics using sequencing for 3′ poly(A) tails of in vitro-transcribed mRNA

Jina Seo, Hyo-Jung Park, Ayoung Oh, Chang Beom Jeong, Sohee Kim, Sojeong Lee, Chuna Kim, Hyeshik Chang, Jae-Hwan Nam, Daechan Park [Molecular Therapy 33(10)(June, 2025)]

N6-methyladenosine modification of HCMV IE1 transcript promotes the repressive state of viral genome to achieve latent infection

Heena Jeong, Nagyeong Yeo, Hyeonseo Hwang, Junhyun Park, Daehyun Baek, Kwangseog Ahn [PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 122(24)(June, 2025)]

Structural basis of the catalytic and allosteric mechanism of bacterial acetyltransferase PatZ

Jun Bae Park, Gwanwoo Lee, Yu-Yeon Han, Dongwook Kim, Kyoo Heo, Jeesoo Kim, Juhee Park, Hyosuk Yun, Chul Won Lee, Hyun-Soo Cho, Jong-Seo Kim, Martin Steinegger, Yeong-Jae Seok, Soung-Hun Roh [PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 122(24)(June, 2025)]

Mitochondrial fumarate inhibits Parkin-mediated mitophagy

Su Jin Ham, Sunhoe Bang, Daihn Woo, Jae-Yoon Jo, Takwon Yoo, Eunju Yoon, Yeonju Kyoung, Daehyun Baek, Jong-Seo Kim, Jongkyeong Chung [Molecular Cell 85(12), 2287-2302.e9(June, 2025)]

SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases

Doyeong Ku, Yewon Yang, Youngran Park, Daesong Jang, Namseok Lee, Yong-ki Lee, Keonyong Lee, Jaeseon Lee, Yeon Bi Han, Soojin Jang, Se Rim Choi, You-Jung Ha, Yong Seok Choi, Woo-Jin Jeong, Yun Jong Lee, Kyung Jin Lee, Seunghee Cha, Yoosik Kim [CELL REPORTS 44(5)(May, 2025)]

Human cytomegalovirus infection induces L1 expression through UL38-dependent mTOR-KAP1 pathway

Sehong Park, Jiseok Jeong, Kwangseog Ahn [PLoS ONE 20(4), e0320512-(April, 2025)]

Mechanisms of chemotherapy failure in refractory/relapsed acute myeloid leukemia: the role of cytarabine resistance and mitochondrial metabolism

Soo Yeon Chae, Se-Young Jang, Jinhui Kim, Sehyun Hwang, Disha Malani, Olli Kallioniemi, Seung Gyu Yun, Jong-Seo Kim, Hugh I Kim [CELL DEATH & DISEASE 16(1), 331-(April, 2025)]

Exogenous RNA surveillance by proton-sensing TRIM25

Myeonghwan Kim, Youngjoon Pyo, Seong-In Hyun, Minseok Jeong, Yeon Choi, V Narry Kim [Science 388(6742)(April, 2025)]