Center for Relativistic Laser Science

◆ Research Interests

Aging and programmed cell death in plants
RNA-based regulation of leaf aging
Synthetic genetics-based aging reprogramming

◆ Education

1991, Michigan State University, Ph. D. in Genetics
1985, Sogang University, M.S. in Biology
1982, Sognag University, B. S. in Biology

◆ Professional Experience

2012.09 - Present : Associate Professor, DGIST, Korea
2005.03 - 2012. 08 : Assistant Professor, Associate Professor, Jeju National University

Laboratory for Complex Biology

◆ Introduction to Research

Aging in leaves is critical for plant’s fitness as nutrient relocalization from leaves to reproducing seeds is achieved through this process.
Aging process in plants involves a coordinated action at the cellular, tissue, organ, and organism levels under the control of a highly regulated genetic program.
We are taking systems biology approach to obtain insights into age-associated complex regulatory networks and understand the aging process in leaves.
Synthetic genetic approaches are also taken to reprogram leaf aging based on the key regulatory network for increased biomass. 

◆ Research Publication(selected)

1. Kang HG, Kim J, Kim B, Jeong H, Choi SH, Kim EK, Lee HY, Lim PO (2011) Overexpression of FTL1/DDF1, an AP2 transcription factor, enhances tolerance to cold, drought, and heat stresses in Arabidopsis thaliana. Plant Science 180(4):634-641.
2.  Woo HR, Kim JH, Kim JY, Kim JS, Lee U, Song IJ, Kim JH, Lee HY, Nam HG, Lim PO (2010) The RAV1 transcription factor positively regulates leaf senescence in  Arabidopsis. J Exp Bot. 61(14):3947–3957.
3.  Lim PO, Lee IC, Kim J, Kim HJ, Ryu JS, Woo HR, Nam HG (2010) Auxin response factor 2 (ARF2) plays a major role in regulating auxin-mediated leaf longevity. J Exp Bot. 61(5):1419-1430.
4.  Kim JH, Woo HR, Kim J, Lim PO, Lee IC, Choi SH, Hwang D, Nam HG (2009) Trifurcate feed-forward regulation of age-dependent cell death involving miR164 in Arabidopsis. Science. 323:1053-1057.
5.  Lim PO, Kim Y, Breeze E, Koo JC, Woo HR, Ryu JS, Park DH, Beynon J, Tabrett A, Buchanan-Wollaston V, Nam HG. (2007) Overexpression of a chromatin architecture-controlling AT-hook protein extends leaf longevity and increases the post-harvest storage life of plants. Plant J. 52(6):1140-53.

◆ Invited Review Articles

1.  Lim PO et al. (2007) Leaf senescence. Annu Rev Plant Biol. 58:115-36
2.  Lim PO et al. (2003) Molecular genetics of leaf senescence in Arabidopsis. Trends in Plant Science 8:272-278.

◆ Patents(selected)
1. Nam HG, Lim PO, Cho SH, ORE7, Gene controlling life span of leaves in plants and method for controlling life span of plants using the same. PCT/KR02/01578, China 02816505.5, CN 1547589A, Europe 02758930.8, EP1 436 324, Australia 02 758 930.8, USA 10/487,225, US-2005-0055745-A1, Reg No. 7,060,875

◆ Research Interests

 Genome biology
 Epigenomics in plants
 Plant senescence

◆ Education

2002: POSTECH (Ph.D. in Life Science)
1999: POSTECH (M.S. in Life Science)
1997: POSTECH (B.S. in Life Science)

◆ Professional Experience

2013~present: Assistant Professor, DGIST, Korea 
2009~2012: Assistant Professor, Dept. of Biology, Chungnam National University, Korea

Major in New Biology

◆ Introduction to Research

Multi-dimensional analysis of Arabidopsis transcriptome leaf across the lifespan
Epigenomic analysis of Arabidopsis leaf lifespan

 ◆ Research Publication(selected)

1. Yoonkang Hur, Jin Hee Kim, Dong-Joon Lee, Kyung Min Chung, and Hye Ryun Woo. Overexpression of AtCHX24, a member of the cation/H+ exchangers, accelerates leaf senescence in Arabidopsis thaliana (2012). Plant science 183, 175-182.
2. Tae Hee Lee, Young Ran Kim, Joon Haeng Rhee, Jin-Hong Kim, Hye Ryun Woo, and Kyung Min Chung. Characterization of monoclonal antibodies targeting the RtxA1 toxin of Vibrio vulnificus (2011). Process Biochem 46, 1500-1508.
3. Hye Ryun Woo, Jin Hee Kim, Junyoung Kim, Jeongsik Kim, Ung Lee, In-Ja Song, Jin-Hong Kim, Hyo-Yeon Lee, Hong Gil Nam and Pyung Ok Lim. The RAV1 transcription factor positively regulates leaf senescence in Arabidopsis (2010). J Exp Bot. 61(14), 3947-3957.
4. Pyung Ok Lim, In Chul Lee, Junyoung Kim, Hyo Jung Kim, Jong Sang Ryu, Hye Ryun Woo* and Hong Gil Nam*. Auxin response factor 2 (ARF2) plays a major role in regulating auxin-mediated leaf longevity (2010). J Exp Bot. 61(5), 1419-1430. (*Corresponding authors)
5. Jin Hee Kim*, Hye Ryun Woo*, Jeongsik Kim, Pyung Ok Lim, In Chul Lee, Seung Hee Choi, Daehee Hwang and Hong Gil Nam. Trifurcate feed-forward regulation of age-dependent cell death involving miR164 in Arabidopsis (2009). Science 323, 1053-1057. (*These authors contributed equally to this work.)

[Biography]

◆ Educational Background

1990: Ph. D., Department of Psychobiology, University of California, Irvine

1979 - 1985: B.S. and M.S., Dept. of Zoology, Seoul National University

◆ Professional Career

2013 - Present: Professor, Department of Biological Sciences, KAIST.

1995 - 2012: Assistant, Associate, Full Professor, Ajou University School of Medicine.

1994 - 1995: Assistant Research Professor, Department of Psychology, University of Arizona, USA. 1990 - 1995: Post-Doc., Department of Psychology, University of Arizona, USA.

◆ Contact

Tel: +82-42-350-2612 (Office) / +82-42-350-2652 (Lab) Fax: +82-42-350-2610 Email:mwjung@kaist.ac.kr https://sites.google.com/site/systemsneurolaboratory/

[Research Areas]

◆ Decision making Decision making in a dynamic environment consists of multiple underlying processes such as representing values of potential choices, making choices based on these values, and updating the values based on the outcome of a choice. We investigate how these processes are implemented in the fronto-basal ganglia loop. We also investigate how multiple decision making systems (trial-and-error-based vs. deliberate control system) interact to yield a final action selection. To this end, we examine neuronal ensemble activity and manipulate neural activity in rodents, because they allow largesize neuronal ensemble recordings, use of genetically-modified animals, and relatively easy application of optogenetic techniques on top of that the nervous system is much simpler than that of the primate. We also conduct theoretical studies of reinforcement learning and neural network modeling.

◆ Event memory One of the central issues in cognitive neuroscience is to understand the neural basis of event memory. Although it is well known that the hippocampus plays a crucial role in encoding event memory, its underlying neural mechanisms remain unclear despite a long history of intensive investigations. We investigate how different types of information are integrated in the hippocampus during the formation of event memory (‘what happened’ ‘where’ and ‘when’) by conducting behavioral and neurophysiological experiments in rats. We also use genetically-engineered mice with specific disruptions in distinct sub-regions of the hippocampus (dentate gyrus, CA3 and CA1) to investigate functional roles played by each hippocampal sub-region in encoding event memory.

◆ Interval timing Time and space are fundamental dimensions for all living organisms. The ability to anticipate the timing of predictable events is critical for survival in many animal species including humans. In particular, time interval estimation in the range of a few seconds (interval timing) is involved in numerous behavioral processes. However, it is unknown how interval timing-related functions are implemented in the brain in large part because of the paucity of physiological studies. In order to investigate how the brain keeps track of the elapse of time, we record and analyze neuronal activity in different brain structures as rodents perform various time interval discrimination tasks. [Publication List]

◆ Publication List

1. Lee H, Ghim JW, Kim H, Lee D, Jung MW. (2012) Hippocampal neural correlates for values of experienced events. J. Neurosci. 32(43):15053-65. 

2. Lee JW, Kim WR, Sun W, Jung MW. (2012) Disruption of dentate gyrus blocks effect of visual input on spatial firing of CA1 neurons. J. Neurosci. 32(38):12999-3003.

3. Lee D, Seo H, Jung MW. (2012) Neural basis of reinforcement learning and decision making. Ann. Rev. Neurosci. 35:287-308.

4. Sul JH, Jo S, Lee D, Jung MW. (2011) Role of rodent secondary motor cortex in value-based action selection. Nature Neurosci. 14(9):1202-8

5. Sul JH, Kim H, Huh N, Lee D, Jung MW. (2010) Distinct roles of rodent orbitofrontal and medial prefrontal cortex in decision making. Neuron. 66(3):449-60.

◆ Educational Background

2007 Ph. D., School of Biological Sciences, Seoul National University

2002 B.S. Department of Biology Education, Seoul National University

◆ Professional Career

2018 - Present: Associate Professor, Department of Biological Sciences, KAIST.

2013 - 2018: Assistant Professor, Department of Biological Sciences, KAIST.

2009 - 2013: Postdoctoral Research Fellow, University of California, Berkeley / HHMI

2007 - 2009: Postdoctoral Research Fellow, School of Biological Sciences, Seoul National University.

◆ Contact

Tel: +82-42-350-2613 (Office) / +82-42-350-2653(Lab)
Email:shlee1@kaist.ac.kr 
https://sites.google.com/site/leelab2013/

[Research Areas]

How do we perceive the world? Inputs from the external world, i.e., sensory stimuli, need to be actively processed in the brain to be transformed into a "percept". Sensory processing (computation of sensory stimuli in the brain) is the gateway to sensory perception, and efficient sensory processing is required for the perceptual behavior of the animal. Switching from a drowsy, inattentive behavioral state to an aroused, attentive state is crucial for the effective perception of relevant sensory stimuli and execution of cognitively demanding tasks. How do our brain circuits execute this amazing function? We answer this question by studying the following topics in the mouse animal model:

- Modality-specific sensory processing

- Selective attention and modulation of perception

- Multisensory integration and cross-modal binding

- Perceptual decision and sensorimotor transformation

- Social perception

Our research aims to unravel brain circuits that are important for selective attention, multisensory integration, and behavioral decision, which are critical for cognitive and perceptual behaviors. Insights from our study should be broadly applicable to the treatment of psychiatric disorders including attention deficit disorder, autism, and schizophrenia.

◆ Publication List

1. Kim J, Ma DH, Jung E, CHoi I, Lee SH. (2021) Gated feedforward inhibition in the frontal cortex releases goal-directed action. Nature Neuroscience. 32(43):15053-65.

2. Song YH, Yoon JW, Lee SH. (2021) The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders. Experimental & Molecular Medicine. 53: 328-338.

3. Song YH, Hwang YS, Kim K, Lee HR, Kim JH, Maclachlan C, Dubois A, Jung MW, Petersen CCH, Knott G, Lee SH, Lee SH. (2020) Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1. Science Advances. 6(17): DOI: 10.1126/sciadv.aaz0517.

4. Choi I, Lee JY, Lee SH. (2018) Bottom-up and top-down modulation of multisensory integration. Current Opinion in Neurobiology. 52:115-122.

5. Song YH, Kim JH, Jeong HW, Choi I, Jeong D, Kim K, Lee SH. (2017) A neural circuit for auditory dominance over visual perception. Neuron. 93: 940-954.

6. Kim J, Jung AH, Jeong D, Choi I, Kim K, Shin S, Kim SJ, Lee SH. (2016) Selectivity of neuromodulatory projections from the basal forebrain and locus coeruleus to primary sensory cortices. Journal of Neuroscience. 36(19):5314-5327.

Ph.D. Ulsan National Institute of Science and Technology (UNIST), Korea (2018)

(Advisor: Prof. Myoung Soo Lah)

Ph.D. University of Southampton, United Kingdom (2018)

(Advisor: Prof. Richard Brown)

Intergrated MS&PhD

Postdoctoral Scholar (2022/04 ~ )

Technical University of Munich, Germany (2021)

(Advisor: Lukas Hintermann)

Sungwoo Hong's Group

Ph.D. Xiamen University, China (2022)

(Advisor: Prof. Lei Gong)

Mu-Hyun Baik's Group

Ph.D. CSIR-National Chemical Laboratory, Pune, India

Postdoctoral Scholar (2022/12 ~ )

Ph.D. Indian Institute of Technology Delhi, India (2022)

(Advisor: Prof. Ravi P. Singh)

Postdoctoral Scholar (2022/12 ~ )

Ph.D. Nanjing University, China (2022)

(Advisor: Prof. Yi Pan)

Postdoctoral Scholar (2023/03 ~)

Ph.D. Korea Advanced Institute Science and Technology (KAIST), Korea (2023)

(Advisor: Prof. Sukbok Chang)

Postdoc (2022/12~)

Ph.D. NC state University, US

Postdoctoral Scholar (2023/03)

Ph.D. KAIST(2023)

Postdoctoral Scholar (2023/03)

Ph.D. KAIST(2023)

Integrated MS&PhD (2020/09)

Integrated MS&PhD (2021/03)

Integrated MS&PhD (2021/03)

Integrated MS&PhD (2021/09)

Integrated MS&PhD (2021/09)

Integrated MS&PhD (2022/03)

Integrated MS&PhD (2022/03)

MS (2022/03)

Integrated MS&PhD (2023/03)

Integrated MS&PhD (2023/03)

Integrated MS&PhD (2023/03)

Integrated MS&PhD (2023/03)

Data Science Group

Center for Mathematical and Computational Sciences

Institute for Basic Science (IBS)

Data Science Group

Center for Mathematical and Computational Sciences

Institute for Basic Science (IBS)

Data Science Laboratory

School of Computing

Korea Advanced Institute of Science and Technology (KAIST)

Data Science Laboratory

School of Computing

Korea Advanced Institute of Science and Technology (KAIST)

Assistant Professor (2017-present)

School of Northeast Asian Studies

Incheon National University, South Korea

인천대학교 동북아국제통상학부 조교수 양현주

- Ph.D. Student at Department of Geography, National University of Singapore (from January 2020)

- Researcher at The Institute for Korean Regional Studies(IKRS), Seoul National University

  (until December 2019)

- Faculty Affairs

- Human Resource

- Planning & Budget

- Equipment Purchase

- FACS room

- Facilities Management (Cell sorter, FACS, etc)