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IBS Institute for Basic Science

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Director
Current
Alummni
Alummni
Alummni

SukWon Hwang
Research Fellow
CNIR
+82-31-299-6992
dupong76

Wonmin Choi
Ph.D Student
PI: Seong-Gi Kim
Department of Biomedical Engineering
wonmin.mri

Yoon Gi Chung
Research Fellow
CNIR
+82-31-299-6722
ygchung

Yong Wook Hong
CNIR
031-290-5917
yongwook_hong

Junsik Park
Ph.D Student
031-299-4408
jsp87works

Jongwook Song
Ph.D Student
031-299-4408
keltrol

Byungjae Hwang
Master student
031-299-4408
myway_style

Jeongtaek Won
Master student
SKKU, Department of Biological Science
+82-31-290-5918
witbwitb

Hyunkyung Maeng
Ph.D Student
031-299-4408
aodrud77

Eunji Lim
Ph.D Student
031-299-4408
eeuunngg

Sunyoung Chae
Ph.D Student
PI: Junghee Lee
Department of Health Sciences and Technology
onlycsy

Hongtae Kim
Associate Professor
Cancer biology
Department of Biological Sciences
khtcat
http://bio.skku.edu/glter/wiki/Hongtae%20Kim

Information
Lab Name: Cancer biology lab

Introduction
The DNA damage response (DDR) is essential for preserving genomic integrity in eukaryotes. At the start of the DDR network are the ATM and ATR kinases, which impose their regulation on multiple repair pathways via damage-induced phosphorylation. The overall goal of our laboratory is to understand the molecular mechanisms underlying genomic instability and tumorigenesis using DNA damage signaling pathway. The maintenance of genomic integrity following DNA damage depends on the interaction of DNA repair with cell cycle checkpoint controls. The integrity of the DNA damage response pathway is crucial for the prevention of neoplastic transformation, as suggested by the fact that many proteins involved in these pathways are tumor suppressors including p53, ATM, Chk2, RAP80, BRCA1 and BRCA2. Our group has discovered and studied many new components involved in DNA damage pathways. Recently, our group also studied other areas of genomic instability, including mitotic regulation. Our lab is also studying a signal transduction pathway in brain.

Selected Recent Publications
1. Lee NS, Chung HJ, Kim HJ, Lee SY, JJi J, Seo Y, Han SH, Choi M, Yun M, Lee SG, Myung K, Kim Y, Kang HC, Kim H, Nature communication, 2015.

2. Cho HJ, Oh YJ, Han SH, Chung HJ, Kim CH, Lee NS, Kim WJ, Choi JM, Kim H,"Cdk1 protein-mediated phosphorylation of receptor-associated protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M checkpoint and cell survival" J Biol Chem 8;288(6): 3768-76, 2013.

3. Kim H, Lee JE, Shin ES, Yoo YK, Cho JH, Yun MH, Kim YH, Kim SK, Kim HJ, Jang TW, Kwak SM, Kim CS, Ryu JS, "Effect of BRCA1 haplotype on survival of non-small-cell lung cancer patients treated with platinum-based chemotherapy", J Clin Oncol 26(36): 5972-5979, 2008.

4. Hongtae Kim, Jun Huang & Junjie Chen, "CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response", Nature structure& Molecular biology, 14: 710-715, 2007.

5. Hongtae Kim, Junjie Chen* and Xiaochun Yu* (*To whom correspondence should be addressed), "Ubiquitin-binding protein mediates BRCA1-dependent DNA damage responses", Science 316 : 1202-1205, 2007.

Chaejeong Heo
Research Professor
Cellular Neuroscience, Neurogenesis, Neuro-imaging technology development, In vivo two-photon imaging
031-299-4269
neuroheo

Hyejin Jang
Master student
SKKU, School of Chemical Engineering
+82-31-299-4712
jm98147

Daehyun Kim
Master student
PI: Won Mok Shim
Department of Biomedical Engineering
uncj

Sugil Kim
Researcher
Magnetic resonance imaging and its applications, Molecular imaging(chemical exchange sensitive MRI), Ultra fast imaging
031-299-4408
davidsugilkim

Hyunwoo Ryu
Ph.D Student
PI: Minah Suh
Department of Biomedical Engineering
a1sw3

Soomi Kim
Ph.D Student
PI: Hongtae Kim
Department of Biological Sciences
sumi312

Byeonghak Park
Ph.D Student
PI: Tae-il Kim
Department of Chemical Engineering
dhdld1598

Kiyoon Kwon
Ph.D Student
PI: Tae-il Kim
Department of Chemical Engineering
kiyoonb
Optogenetics

Sea Geon Park
Master student
worldofwar

Hyowon Tak
Master student
031-299-7312
tho900

Hyeonseong Im
Master student
031-299-4409
skin119

Eunmi Lee
Administrative Staff
Magagement of equipment&asset, Safety, LMO, Workshop
031-299-4353
sellys12

Joonsung Lee
Principal Researcher
Animal MRI, Rodent functional MRI, Current density imaging for transcranial stimulation
031-299-6992
goplusplus

Junghyun Hahn
Research Professor
Neuro-glia interaction, Dynamics of neurovascular coupling in health and diseases, Roles of CRF as a neuromodulator
031-299-6587
junehahn

Jungryun Lee
Principal Researcher
Network oscillations, State-dependent brain activity, Sensory information processing, Functional brain mapping, Neurophysiology
031-299-4410
jungryun

JaeHwan Kim
Principal Researcher
Neurovascular diseases, whole tissue imaging, Spinal cord injury, Cell therapy
031-299-6587
jhkim74

Hahnsung Kim
Research Fellow
Magnetic Resonance Imaging Methodology
031-299-4410
kimhs22

Suhyung Park
Research Fellow
Magnetic resonance imaging and its applications, signal processing
031-299-4410
me_park

Sohee Lee
Research Fellow
Neurovascular Coupling, Chronic Stress, Cerebrovascular Disease
031-299-4410
ioiguu

Jinyong Park
Researcher
031-299-4406
jinyong1204

Minjung Kim
Researcher
Electrohemical Sensor measurement for in vivo, in vitro
031-290-5917
minjungkim

Juhyun Woo
Researcher
031-290-5917
woojuinkr

Jonguk Kim
Ph.D Student
PI: Tae-il Kim
Department of Chemical Engineering
kjo1687
patterning, dewetting, thin film heater

Ji Sun Kim
Master student
031-299-4409
jsun99m

Taehyung Kim
Master student
PI: Tae-il Kim
Department of Chemical Engineering
esperanzas24

Woojin Jung
Master student
PI: Tae-il Kim
Department of Chemical Engineering
da9da9a

SungHyuk Sunwoo
Master student
PI: Tae-il Kim
Department of Biomedical Engineering
chemdeity

Youngjin Jo
Master student
PI: Tae-il Kim
Department of Chemical Engineering
kinm0426

Juseung Lee
Master student
PI: Tae-il Kim
Department of Chemical Engineering
jeo0512

Sori Lee
Master student
PI: Tae-il Kim
Department of Chemical Engineering
lovely_lsr

Chanho Jung
Master student
PI: Tae-il Kim
Department of Biomedical Engineering
astraeus3

Haeleen Hong
Master student
PI: Tae-il Kim
Department of Chemical Engineering
kirin_h

신일재
Master student
PI: Tae-il Kim
Department of Chemical Engineering
gom325

HaeRi Park
Technical Staff
Animal technician
031-299-4406
goflwkd1236

Dohyun Bae
Master student
031-299-4240
bdh29392568

Hee-Jin Kwak
Researcher
031-299-5917
bioheejin

Jooyeun Han
Technical Staff
Animal technician
031-299-4406

Sae Bo Mi Park
Research Fellow
031-299-4249
sbmpark

Sangwoo Kim
Postdoctoral Fellow
Functional connectivity of brain circuitry using optogenetic fMRI
031-299-4410
jimmy2505

Youngmi Lee
Professor
Electrochemical Biosensing and Electrocatalysis
Department of Chemistry and Nanoscience, Ewha Womans University
youngmilee

Woo Chul Jeong
Postdoctoral Fellow
Simultaneous BOLD-fMRI, Local Field Potential measurements
031-299-4410
woochuls28

Hyunjeong Lee
Researcher
PI: Yee Joon Kim
Center for Cognition and Sociality, Institute for Basic Science
iamleehj

Eunsung Kang
Master student
PI: Yong Ho Kim
Graduate School of Nano Science and Technology
dmstjdrkd1

Junichiro KAWAMURA
Research fields : beyond the Standard Model phenomenology, collider phenomenology, dark matter, cosmology
Tel : 042-878-8430
jkawa

Miok Park(YSF)
Research fields : Quantum Gravity, General Relativity
Tel. 042-878-8433
miokpark76

Krzysztof Jodlowski
Physics Beyond the Standard Model, Particle Dark Matter Phenomenology
042-878-8436
k.jodlowski

Adil Jueid
Physics Beyond the Standard Model, QCD and collider physics, and Machine Learning.
042-878-8441
adiljueid

Jong-Wan Lee
Physics Beyond the Standard Model, Lattice Field Theory
042-878-8431
j.w.lee

Minxi He
Theoretical Cosmology and High Energy Physics
042-878-8419
heminxi

Jin Sun
New physics beyond SM, flavor physics and CP violation, neutrino physics, axion physics
sunjin0810

Suruj Jyoti Das
Dark matter phenomenology, Baryon asymmetry, PBH, Gravitational waves.
042-878-8421
surujd

Sung Hak Lim
Physics Beyond the Standard Model, Theoretical High Energy Physics with Machine Learning.
042-878-8456
sunghak.lim

sougata Ganguly
Physics Beyond the Standard Model, Particle Cosmology
sganguly0205

Huayang Song
Physics Beyond the Standard Model
huayangs1990

Sören Kotlewski
Superstring and Supergravity
kotlewski2607

Jaeyoung Park
Seoul National University

Kim, Junghyun
Superstring and Supergravity
042-878-8401
wjdgus06

Sin-Hyeog Im
Research Fellow
Immune regulation and tolerance
+82-54-279-2356
imsh
http://irt.postech.ac.kr/

Information
Major Experience

1991-1996 Senior Research Scientist, Research Center of Chong Kun Dang Pharmaceutical Company, Seoul, Korea

2001-2003 Postdoctoral Fellow, Department of Pathology Harvard Medical School

2004-2008 Assistant Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)

2008-2012 Associate Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)

2012-2013 Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)

2014~present Professor, Division of Integrative Biosciences and Biotechnology, POSTECH

Research Interests

Role of transcription factors (Ets1 and NFAT1) in immune regulation and tolerance

Molecular mechanism of IL-10 gene regulation in lymphocytes and dendritic cells

Elucidation of the signaling pathways for IL-10 expression induced by commensal bacteria and probiotics.

Elucidation of the mechanism of probiotics-induced immune modulation

Characterization of regulatory DCs and regulatory T cells (iTreg) cells induced by probiotics

Development of antigen-specific immunotherapy for autoimmune disorders (Myasthenia gravis and rheumatoid arthritis)

Selected Publications

1. Kwon HK, Kim GC, Kim Y, Hwang W, Jash A, Sahoo A Nam JH, and Im SH. Amelioration of experimental autoimmune encephalomyelitis by probiotics mixture is mediated by a shift in T helper cell immune response. Clinical Immunology. 2013;146(3):217-227

2. Chae CS, Kwon HK, Hwang JS, Im SH. Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis. PLoS One. 2012;7(12):e52119

3. Lee IH, Kwon HK, An S, Kim D, Kim S, Yu MK, Lee JH, Lee TS, Im SH, Jon S. Imageable Antigen-Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo. Angew Chem Int Ed Engl. 2012;51(35):8800-5

4. Jash A, Sahoo A, Kim GC, Chae CS, Hwang JS, Kim JE, ImSH. NFAT induced permissive chromatin modification facilitates NF-κB mediated interleukin-9 (IL-9) transactivation. J Biol Chem. 2012;287(19):15445-57

5. Jash A, Yun KS, Sahoo A, So JS, Im SH. Looping mediated interaction between the promoter and 3′ UTR regulates type II collagen expression in chondrocytes. PLoS One. 2012;7(7):e40828.

6. Lee CG, Kwon HK, Sahoo A, Won H, So JS, Hwang JS, Chae CS, Kim GC, So HS, Hwang ES, Grenningloh R, Ho IC and ImSH. Interaction of Ets-1 with HDAC1 represses IL-10 expression in T helper 1 cells. J Immunol. 2012;188(5):2244-253

7. Son JS, Chae CS, Hwang JS, Park ZY, Im SH. Enhanced chromatin accessibility and recruitment of JUNB mediate the sustained IL-4 expression in NFAT1 deficient T helper 2 cells. PLoS One. 2011. 6(7): e22042

8. Lee IH, An S, Yu MK, Kwon HK, Im SH, Jon S. Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates. J Control Release. 2011; 155(3):435-41

9. Sahoo A, Lee CG, Jash A, Son JS, Kim G, Kwon HK, So JS, Im SH. Stat6 and c-Jun Mediate Th2 Cell-Specific IL-24 Gene Expression. J Immunol. 2011;186(7):4098-109

10. So JS, Song MK, Kwon HK a, Lee CG, Chae CS, Sahoo A, Jash A, Lee SH, Park ZY and Im SH. Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis. Life Sci. 2011;88(7-8):358-66

11. Kwon HK, Lee CG, Jae-Seon Soa, Chae CS, Hwang JS, Sahoo A, Nam JH, Rhee JH, Hwang KC, and Im SH Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders; Proc Natl Acad Sci U S A. 2010;107(5):2159-64. Commented by J Allergy Clin Immunol . May 2010. Page 953

12. Sahoo A and Im SH Interleukin and Interleukin Receptor Diversity: Role of Alternative Splicing. Int Rev Immunol. 2010;29(1):77-109

13. Lee CG, Won H, Maeng KE, Kwon HK, So JS, Sahoo A, Lee SH, Park ZY, ImSH. IRF4 regulates IL-10 gene expression in CD4+ T cells through differential nuclear translocation. Cell Immunol 2011;268: 97-104

14. Yun KS, So JS, Jash A and Im SH Lef1 regulates transcription through gene looping. J Immunol 2009 Oct 15;183(8):5129-37

15. CG Lee, KH Kang, JS So, HK Kwon, JS Son, MK Song, A Sahoo, HJ Yi, KC Hwang, T Matsuyama, K Yui, SH Im. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol. 2009 Feb;46(4):613-21

16. Kwon HK, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8(+) T cells. Cancer Lett. 2009; 278(2): 174-182

17. Lee CG, Kang KH, So JS, Kwon HK, JS Son JS, Song MK, Sahoo A, HJ HJ, KC Hwang, Matsuyama T, Yui K, Im SH. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol. 2009;46(4):613-21

18. Sahoo A, Jung YM, Kwon HK, Yi HJi, Lee S, Chang S, Park ZY, Hwang KC, Im SH. A novel splicing variant of mouse IL-24 antagonizes IL-24-induced apoptosis. J Biol Chem. 2008. 43: 28860-28872.

19. Yi HJ, CS Chae, JS So, ST Tzartos, MC Souroujon, S Fuchs, SH Im. Suppression of Experimental Myasthenia Gravis by a B-cell Epitope-Free Recombinant Acetylcholine Receptor. Mol Immunol. 2008.09.15. 46(1):192-201

20. So JS, CG Lee, HK Kwon ,HJ Yi, CS Chae, JA Park, KC Hwang, SH Im. Lactobacillus casei potentiate induction of oral tolerance in experimental arthritis. Mol Immunol. 2008.09.18. 46(1):172-180

21. So JS, HK Kwon, CG Lee, HJ Yi, JA Park, SY Lim, KC Hwang, YH Jeon, SH Im. Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions. Mol Immunol. 2008.02.19. 45(9):2690-2699

Dipayan Rudra
Research Fellow
T-reg Cell
+82-54-279-9865
rudrad
https://sites.google.com/site/dipayanrudralab/

Jae Ho Cho
Research Fellow
T-cell Homestasis
+82-54-279-8769
jhcho90
T-cell Homestasis

You Jeong Lee
Research Fellow
T-cell Development
+82-54-279-2359
youjeong77

Kwangsoon Kim
Research Fellow
Mutualism between host immune system and commensal bacteria
+82-54-279-8727
kskim27
http://tcb.postech.ac.kr/index.php

Daehee Han
Research Fellow
Role of Dendritic cells in the context of gut immune homeostasis
+82-54-279-8721
theday
http://tcb.postech.ac.kr/index.php

Sungwook Hong
Research Fellow
T-cell Biology
+82-54-279-8721
rozhzor
http://tcb.postech.ac.kr/index.php

Sophie Hyun-Ja Ko
Research Fellow
The role of antigen presenting cells in mucosal immunity
+82-54-279-8684
sophieko
http://tcb.postech.ac.kr/index.php

Choong-Gu Lee
Research Fellow
Immune Regulation and Tolerance
+82-54-279-0644
zuguri81
http://irt.postech.ac.kr/

Ravi Verma
Research Fellow
Immune Regulation and Tolerance
+82-54-279-0646
ravi14
http://irt.postech.ac.kr/

Gi-Cheon Kim
Research Fellow
Immune Regulation and Tolerance
+82-54-279-0647
mission35
http://irt.postech.ac.kr/index.html

Won Hwang
Research Fellow
Immune Regulation and Tolerance
+82-54-279-0644
wonwon
http://irt.postech.ac.kr/index.html

Hye-Ji Kang
Research Fellow
Immune Regulation and Tolerance
+82-54-279-0647
hjkang
http://irt.postech.ac.kr/

Heeok Kim
Research Fellow
T-cell Homestasis
+82-54-279-9866
Heekim14

Nguyen Thi Hong Nhung
Research Fellow
T-cell Development
+82-54-279-8797
hnhung16

Ambarnil Ghosh
Research Fellow
Immune Regulation and Tolerance &T-reg Cell
+82-54-279-0647
ambarnilghosh

Sun-Hee Park
Researcher
Immune Regulation and Tolerance
+82-54-279-0643
ddony369

Jin-A Park
Researcher
Immune Regulation and Tolerance
+82-54-279-0646
jina13

이승준(Seung Jun Lee)
Ph.D. candidate
leeseungjun

이시우(Si Woo Lee)
Ph.D. candidate
siwoolee

이현화(Hyunhwa Lee)
Ph.D. candidate
hyunhwalee

김재은(Jae-Eun Kim)
Ph.D. candidate
kje105

최한슬(Hanseul Choi)
Ph.D. candidate
hschoi8

송희찬(Hee Chan Song)
Ph.D. candidate
hcsong

김희영(Heeyoung Kim)
Ph.D. candidate
hy449

고태원(Tae Won Go)
Ph.D. candidate
taewongo

김택승(Taek-Seung Kim)
Ph.D. candidate
tskim329

강민철(Mincheol Kang)
M.S. candidate
mincheolkang1

송경재(Kyoungjae Song)
M.S. candidate
skj0519

Prof. Hyunjoon Song
Invited Research Fellow
Research Interest: Basic study of structure-property relationship in nano-objects
hsong

Prof. Hyunwoo Kim
Invited Research Fellow
Research Interest: Organic synthesis, asymmetric catalysis, molecular recognition, computational chemistry, green chemistry
hwk34